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Follow your doctor's dosing instructions very carefully Overview Xyzal (Levocetirizine) is an allergy medication that is available over the counter beginning Spring 2017. Xyzal vs Zyrtec ® On first dose, Xyzal provides the same relief as Zyrtec. Generic and Brand drugs online without Prescription. Yes, Xyzal Allergy 24HR is available without a prescription as an over-the-counter (OTC) product for treatment of symptoms due to seasonal and year-round allergies. Allergies Instead of Allegra (fexofenadine), Clarinex (desloratadine), or. Since both medications have a common core chemical structure, Zyrtec and Xyzal generally have the same level of effectiveness, onset of action, and range of allergy symptoms treated. It is the third of Sanofi’s prescription drugs to. Levocetirizine may also be used for purposes not listed in this medication guide. 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